July 18, 2002
Cool Shift Interview With R.U. Sirius

R.U. SIRIUS UNPLUGGED
--One of the earliest adopters of cyberculture, the co-founder of Mondo 2000 has drifted away from tech-chic. Klint Finley asks him about then and now.

S: To change the subject somewhat, where do we stand on the war on drugs right now? Is it more or less important than it was, say, two years ago?

RU: It’s all sort of integrated into the war on terror, and there’s a lot of complex connections there. It’s amazing that it’s all happening in Afghanistan, which is sort of a nexus for the drug underground and also turns out to be the nexus for Al Quaeda and the place where America wants to build an oil pipeline and the place where we have our troops and bombs. And all those things converge. Narcopolitics, as much as class, is at the center of politics in our time. I don’t think any of that has changed. You also see this integration in Columbia where they’re fighting over drugs and they’re also fighting against leftists and they’re fighting for their oil interests -- it’s still rather the same story. On the positive side of course, Europeans almost uniformly are liberalizing drug laws. I don’t know how things are in Canada... I think Vancouver is pretty liberal.

S: Do you think there’s a potential use for psychedelics in psychotherapy?

RU: Yeah, I’ve always thought it was a useful tool. The great thing about having a guide, rather than doing it on your own or in a party, is that it grants permission to take a pretty walloping, great massive dose and go through changes without having to worry about what kind of incursions might occur during the trip. I think if it could be approved for psychotherapy, that would be a tremendous step in the right direction. There’s basically two schools of thought on ending the drug war. One is the libertarian point of view, which is that it should be legalized because it’s a cognitive liberty, a matter of personal choice. And then there’s the attempt to medicalize the situation... harm reduction and so forth. And while I agree with the libertarian view on that, I think medicalization is more likely to be allowed.

Posted by Lisa at 10:05 AM
Artificial Blood Not Quite Here Yet

See the Wired article by Wil McCarthy:
Strange Blood
--Cataclysmic shortages. Tainted supplies. There is a solution: artificial blood..

To truly end blood shortages and the fears that help produce them, hospitals would need a fluid that's laboratory pure, universally compatible with any human blood or tissue type, and indefinitely storable at room temperature. Most important, it would have to perform the function of oxygen delivery, so far the most elusive function to mimic in efforts to create fake blood. Simply adding oxygen-carrying hemoglobin to a substance like saline won't work - the raw hemoglobin molecule turns out to be both short-lived and toxic to the kidneys and liver unless surrounded by the fatty envelope of the red cell. And numerous other creative workarounds - like encapsulating the molecules in tiny globs of fat or chaining them together into polymers - have failed. Oxygen and CO2 can be dissolved directly into droplets of liquid perfluorocarbon, which holds and releases the two gases about as efficiently as hemoglobin does; when oxygenated, this liquid is even breathable - remember the rat in The Abyss ? This approach too, however, produces side effects, from toxicity to allergies to exhaling an ozone-depleting gas.

Only one oxygen-carrying blood substitute has ever been approved by the FDA. That was Fluosol, a perfluorocarbon additive developed in the US and marketed by Japan's Green Cross corporation from 1989 to 1993, during which time it was infused into some 13,000 patients in the US annually. Unfortunately, Fluosol was a frozen, two-part drug that had to be thawed and mixed immediately prior to use, and in large doses it required patients to breathe pure oxygen (potentially toxic) for the weeks it took their natural blood supply to recover. Meanwhile, doctors had to keep pumping the stuff in every 12 hours or the patient would die, bloodless in a cloud of exhaled fluorocarbons. Fluosol was eventually pulled off the market.

That hasn't stopped others from trying. Today around 10 companies are pushing blood substitutes through the FDA approval process.

Posted by Lisa at 09:55 AM
Elcomsoft Explains The Awful Truth About Adobe's E-Book Encryption. Again.

From The Shifted Librarian and 24-hour Drive Thru Weblog

Here's the actual email posting from Vladamir Katalov
(http://online.securityfocus.com/archive/1/281973).

I've created another copy of the email on my own website for safe keeping.

Posted by Lisa at 09:34 AM